Michael Leitges Selected Research

PKC-3 protein

1/2018	Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
1/2017	Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
1/2014	Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.
2/2010	Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications.
6/2009	The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.
1/2009	Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.

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Michael Leitges Research Topics

Disease

19	Neoplasms (Cancer) 11/2021 - 05/2002
11	Insulin Resistance 01/2019 - 08/2007
11	Carcinogenesis 10/2017 - 10/2004
9	Inflammation (Inflammations) 01/2016 - 10/2003
7	Hyperinsulinism (Hyperinsulinemia) 01/2021 - 08/2007
7	Obesity 01/2017 - 06/2009
6	Glucose Intolerance 01/2017 - 08/2007
6	Hyperglycemia 08/2013 - 08/2004
5	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 01/2012
5	Diabetic Nephropathies (Diabetic Nephropathy) 07/2012 - 08/2004
5	Fibrosis (Cirrhosis) 07/2009 - 04/2005
4	Type 2 Diabetes Mellitus (MODY) 01/2019 - 10/2007
4	Albuminuria 07/2012 - 08/2004
4	Ischemia 04/2008 - 01/2002
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 10/2016
3	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020 - 08/2002
3	Thrombosis (Thrombus) 10/2017 - 07/2010
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2016 - 08/2007
3	Atherosclerosis 12/2014 - 04/2009
3	Hypersensitivity (Allergy) 01/2014 - 04/2005
3	Necrosis 09/2012 - 10/2003
3	Colonic Neoplasms (Colon Cancer) 02/2009 - 10/2004
3	Hypertrophy 04/2007 - 04/2005
2	Lung Neoplasms (Lung Cancer) 02/2022 - 10/2009
2	Glioblastoma (Glioblastoma Multiforme) 11/2021 - 08/2008
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2021 - 01/2013
2	Adenocarcinoma of Lung 12/2019 - 12/2019
2	Diabetes Mellitus 08/2013 - 11/2006
2	Carcinoma (Carcinomatosis) 04/2013 - 08/2009
2	Abdominal Obesity 04/2012 - 08/2007
2	Hypertriglyceridemia 04/2012 - 06/2009
2	Cardiomegaly (Heart Hypertrophy) 03/2012 - 04/2005
2	Blindness (Hysterical Blindness) 02/2010 - 01/2002
2	Infections 10/2007 - 11/2006
1	Ovarian Neoplasms (Ovarian Cancer) 02/2022
1	Pancreatitis 02/2022
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2021

Drug/Important Bio-Agent (IBA)

23	Protein Kinase CIBA 01/2021 - 10/2003
15	Protein Kinases (Protein Kinase)IBA 11/2021 - 05/2002
15	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 09/2003
14	Protein Isoforms (Isoforms)IBA 01/2019 - 01/2002
13	Insulin (Novolin)FDA Link 01/2021 - 11/2006
11	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2002
10	Phosphotransferases (Kinase)IBA 01/2016 - 10/2003
8	protein kinase C lambdaIBA 02/2022 - 08/2007
7	LipidsIBA 01/2019 - 08/2007
7	CytokinesIBA 01/2012 - 01/2002
6	PKC-3 proteinIBA 01/2018 - 01/2009
5	CollagenIBA 11/2016 - 04/2005
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2013 - 01/2002
5	NF-kappa B (NF-kB)IBA 02/2010 - 08/2002
5	Protein Kinase C betaIBA 07/2009 - 01/2002
4	Pharmaceutical PreparationsIBA 11/2021 - 07/2009
4	Protein Kinase C-epsilonIBA 08/2009 - 04/2005
4	Protein Kinase C-alphaIBA 07/2009 - 08/2004
3	CateninsIBA 12/2019 - 02/2015
3	IntegrinsIBA 11/2016 - 07/2005
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2016 - 08/2013
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016 - 09/2003
3	AntigensIBA 03/2011 - 05/2006
3	Retinaldehyde (Retinal)IBA 02/2010 - 01/2002
3	ruboxistaurinIBA 07/2009 - 04/2008
3	AzoxymethaneIBA 02/2009 - 10/2004
3	Transforming Growth Factor beta1 (TGF beta 1)IBA 04/2007 - 08/2004
2	Amyloid (Amyloid Fibrils)IBA 01/2021 - 10/2016
2	Peptides (Polypeptides)IBA 01/2021 - 08/2011
2	IsoenzymesIBA 12/2020 - 12/2011
2	ErbB Receptors (EGF Receptor)IBA 02/2015 - 07/2006
2	EnzymesIBA 07/2014 - 01/2013
2	Platelet-Derived Growth FactorIBA 08/2013 - 11/2009
2	Apolipoproteins E (ApoE)IBA 08/2013 - 04/2009
2	TensinsIBA 04/2013 - 08/2009
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 04/2013 - 08/2009
2	p38 Mitogen-Activated Protein KinasesIBA 07/2012 - 04/2005
2	Gold Sodium Thiomalate (Sodium Aurothiomalate)IBA 04/2012 - 10/2009
2	Angiotensin IIIBA 03/2012 - 07/2005
2	Interleukin-6 (Interleukin 6)IBA 07/2010 - 01/2009
2	nephrinIBA 04/2010 - 02/2007
2	beta CateninIBA 02/2009 - 01/2009
2	Messenger RNA (mRNA)IBA 10/2007 - 10/2004
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 04/2007 - 08/2004
2	Streptozocin (Streptozotocin)FDA Link 02/2007 - 08/2004
2	perlecanIBA 02/2007 - 08/2004
2	Immunoglobulin E (IgE)IBA 04/2005 - 04/2005
1	CeruletideIBA 02/2022
1	Auranofin (Ridaura)FDA Link 11/2021
1	Doublecortin-Like KinasesIBA 01/2021
1	Phorbol EstersIBA 12/2020
1	Oncogene Proteins (Oncogene Protein)IBA 12/2020
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2020
1	DiglyceridesIBA 01/2019
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	CarcinogensIBA 01/2018
1	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 01/2018
1	MelanocortinsIBA 01/2017
1	LeptinIBA 01/2017
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2017

Therapy/Procedure

5	Therapeutics 01/2021 - 03/2004
1	Drug Therapy (Chemotherapy) 01/2020